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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:28262
Term: dimethyl sulfoxide
Definition: A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Chemical ID: MESH:D004121
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDDimethyl Sulfoxide results in increased expression of PTGS2 proteinPMID:26497626
Ptgs2multiple interactionsEXP 6480464CTD[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]PMID:26497626
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDDimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]PMID:21878375
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