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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDLead results in increased expression of PTGS2 mRNA; Lead results in increased expression of PTGS2 proteinPMID:25193092 PMID:25596430
Ptgs2multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Lead results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Lead results in increased expression of PTGS2 mRNA]; U 0126 inhibits the reaction [Lead results in increased expression of PTGS2 mRNA]PMID:25596430
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDLead results in increased expression of PTGS2 proteinPMID:22610977
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDLead results in increased expression of PTGS2 mRNA; Lead results in increased expression of PTGS2 proteinPMID:25193092
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[Lead co-treated with APP protein modified form] results in increased expression of PTGS2 proteinPMID:22610977
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