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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:2781
Term: apocynin
Definition: An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C056165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases expressionEXP 6480464CTDacetovanillone results in decreased expression of PTGS2 mRNAPMID:21983654
Ptgs2multiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Pyrogallol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]PMID:17244722 PMID:18414395 PMID:23415682 PMID:26522475 PMID:35944648
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDacetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]PMID:22288910 PMID:24967690 PMID:28495310
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]PMID:24337631 PMID:24967690 PMID:30366073
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