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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of PTGS2 mRNAPMID:29689378
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of PTGS2 mRNAPMID:25068794
Ptgs2decreases expressionISOPtgs2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of PTGS2 mRNAPMID:28085963
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of PTGS2 mRNA; Diethylhexyl Phthalate results in increased expression of PTGS2 proteinPMID:31313480
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of PTGS2 mRNA; Diethylhexyl Phthalate results in increased expression of PTGS2 proteinPMID:29688563 PMID:35500696 PMID:36438553
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 protein]; Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]; MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PTGS2 mRNA]PMID:25068794 PMID:31313480
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]PMID:33316053 PMID:35500696 PMID:36438553
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