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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:10138
Term: [6]-Shogaol
Definition: A monomethoxybenzene that has formula C17H24O3.
Chemical ID: MESH:C040115
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDshogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]PMID:23899529
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDshogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]PMID:18683823
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