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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620272
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gli3
Name: GLI family zinc finger 3
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gli3decreases expressionISOGli3 (Mus musculus)6480464CTDFolic Acid results in decreased expression of GLI3 mRNAPMID:25629700
Gli3multiple interactionsISOGli3 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLI3 mRNA; Folic Acid inhibits the reaction [[GLI3 gene mutant form co-treated with ochratoxin A] results in increased expression of FGF8 mRNA]PMID:17688467 PMID:20938992
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