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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620196 Species: Rattus norvegicus RGD Object: Gene Symbol: Mmp13 Name: matrix metallopeptidase 13

Acc ID: CHEBI:6067 Term: isotretinoin Definition: A retinoic acid that has formula C20H28O2. CasRN: 4759-48-2 Chemical ID: MESH:D015474

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1343267	6480464	CTD	Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA] Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]	PMID:16185265
decreases expression	ISO	RGD:1343267	6480464	CTD	Isotretinoin results in decreased expression of MMP13 protein	PMID:16185265