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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620108
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa2affects expressionEXP 6480464CTDbisphenol A affects the expression of NCOA2 mRNAPMID:32145629
Ncoa2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NCOA2 mRNAPMID:25181051 PMID:34947998
Ncoa2increases expressionEXP 6480464CTDbisphenol A results in increased expression of NCOA2 proteinPMID:19379760 PMID:19590682 PMID:23620208 PMID:24884420
Ncoa2multiple interactionsEXP 6480464CTDbisphenol A inhibits the reaction [Genistein results in decreased expression of NCOA2 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of NCOA2 protein]PMID:24884420
Ncoa2multiple interactionsISONCOA2 (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A promotes the reaction [ESR1 protein binds to NCOA2 protein]; bisphenol A promotes the reaction [ESR2 protein binds to NCOA2 protein]; bisphenol A promotes the reaction [NCOA2 protein binds to THRB protein]; NCOA2 protein promotes the reaction [bisphenol A results in increased activity of ESR1 protein]PMID:10964929 PMID:16328721 PMID:23583298 PMID:29146198 PMID:29389661
Ncoa2multiple interactionsISONcoa2 (Mus musculus)6480464CTDNCOA2 protein promotes the reaction [bisphenol A results in increased expression of ESR2 protein]PMID:27634370
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