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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620108
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NCOA2 mRNAPMID:32109520
Ncoa2affects expressionISONcoa2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NCOA2 mRNAPMID:21570461
Ncoa2increases expressionISONCOA2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of NCOA2 mRNAPMID:12377990 PMID:15345368
Ncoa2multiple interactionsISONCOA2 (Homo sapiens)6480464CTDNCOA2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; NCOA2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; NCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]; NCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1A1 enhancer]; Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1A1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1B1 enhancer]; Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1B1 promoter]PMID:12024042 PMID:15964790 PMID:18842620
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