Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baddecreases phosphorylationEXP 6480464CTDDoxorubicin results in decreased phosphorylation of BAD proteinPMID:27087047
Badincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of BAD proteinPMID:12967636 PMID:18632596 PMID:32691977
Badincreases phosphorylationEXP 6480464CTDDoxorubicin results in increased phosphorylation of BAD proteinPMID:18845810
Badmultiple interactionsEXP 6480464CTDcoenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]; Ginkgo biloba extract inhibits the reaction [Doxorubicin results in increased expression of BAD protein]; HMOX1 protein inhibits the reaction [Doxorubicin results in increased phosphorylation of BAD protein]; HSPD1 protein inhibits the reaction [Doxorubicin results in increased expression of BAD protein]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of BAD protein]PMID:12967636 PMID:18632596 PMID:18845810 PMID:27087047 PMID:32691977
Badaffects expressionISOBAD (Homo sapiens)6480464CTDDoxorubicin affects the expression of BAD mRNAPMID:16705698
Baddecreases expressionISOBad (Mus musculus)6480464CTDDoxorubicin results in decreased expression of BAD mRNAPMID:26873546
Baddecreases expressionISOBAD (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of BAD mRNA; Doxorubicin results in decreased expression of BAD protein modified formPMID:16438844 PMID:29803840
Baddecreases phosphorylationISOBad (Mus musculus)6480464CTDDoxorubicin results in decreased phosphorylation of BAD proteinPMID:18037988 PMID:18948619
Baddecreases phosphorylationISOBAD (Homo sapiens)6480464CTDDoxorubicin results in decreased phosphorylation of BAD proteinPMID:17359293 PMID:20884855
Badincreases expressionISOBad (Mus musculus)6480464CTDDoxorubicin results in increased expression of BAD proteinPMID:17673183
Badincreases expressionISOBAD (Homo sapiens)6480464CTDDoxorubicin results in increased expression of BAD proteinPMID:25339540 PMID:31843629
Badmultiple interactionsISOBad (Mus musculus)6480464CTDCarbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAD protein]PMID:17673183 PMID:18037988
Badmultiple interactionsISOBAD (Homo sapiens)6480464CTDDoxorubicin promotes the reaction [MAPK14 protein results in decreased phosphorylation of BAD protein]; PTEN protein promotes the reaction [Doxorubicin results in decreased expression of BAD protein modified form]; PTEN protein promotes the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]; Sildenafil Citrate promotes the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]PMID:16438844 PMID:16843435 PMID:17359293 PMID:20884855
Go Back to source page   Continue to Ontology report