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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Badincreases expressionEXP 6480464CTDresveratrol results in increased expression of BAD proteinPMID:23262250
Badincreases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of BAD proteinPMID:15345477
Badmultiple interactionsEXP 6480464CTD[8-cyclopentyl-1,3-dimethylxanthine results in decreased activity of ADORA1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BAD protein]; [MRS 1191 results in decreased activity of ADORA3 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BAD protein]PMID:15345477
Baddecreases expressionISOBad (Mus musculus)6480464CTDresveratrol results in decreased expression of BAD proteinPMID:17872969
Badincreases expressionISOBad (Mus musculus)6480464CTDresveratrol results in increased expression of BAD mRNAPMID:22610192
Badincreases expressionISOBAD (Homo sapiens)6480464CTDResveratrol results in increased expression of BAD mRNA; Resveratrol results in increased expression of BAD proteinPMID:16731767 PMID:24331535 PMID:25436977 PMID:31336132 PMID:31883986
Badmultiple interactionsISOBad (Mus musculus)6480464CTD[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of BAD protein]PMID:20370652
Badmultiple interactionsISOBAD (Homo sapiens)6480464CTD[nano-diamino-tetrac co-treated with Resveratrol] inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; [Plant Extracts co-treated with Resveratrol] results in decreased expression of BAD mRNA; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of BAD mRNA]PMID:23557933 PMID:31336132 PMID:31883986
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