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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:7903
Term: pamidronate
Definition: null
Chemical ID: MESH:C019248
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1decreases activityEXP 6480464CTDpamidronate results in decreased activity of PON1 proteinPMID:27387541
Pon1multiple interactionsEXP 6480464CTD[pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetatePMID:27387541
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