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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:75701
Term: sarin
Definition: A racemate composed of equal amounts of (R)- and (S)-sarin. A potent and irreversible inhibitor of acetylcholinesterase that is toxic to the nervous system and is employed as a chemical warfare agent.
Chemical ID: MESH:D012524
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1decreases response to substanceISOPON1 (Homo sapiens)6480464CTDPON1 protein mutant form results in decreased susceptibility to SarinPMID:23159884
Pon1increases hydrolysisISOPON1 (Homo sapiens)6480464CTDPON1 protein mutant form results in increased hydrolysis of Sarin; PON1 protein results in increased hydrolysis of SarinPMID:16331452 PMID:20176006 PMID:23159884
Pon1multiple interactionsISOPON1 (Homo sapiens)6480464CTDPON1 protein inhibits the reaction [Sarin results in decreased activity of ACHE protein]; PON1 protein inhibits the reaction [Sarin results in decreased activity of BCHE protein]PMID:21329748
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