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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:30745
Term: phenylacetic acid
Definition: A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Chemical ID: MESH:C025136
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1increases hydrolysisEXP 6480464CTDPON1 protein results in increased hydrolysis of phenylacetic acidPMID:14668577 PMID:16052486
Pon1multiple interactionsEXP 6480464CTDfluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]PMID:14668577
Pon1affects metabolic processingISOPON1 (Homo sapiens)6480464CTDPON1 protein affects the metabolism of phenylacetic acid; PON1 protein polymorphism affects the metabolism of phenylacetic acidPMID:11304470 PMID:15924216 PMID:16079929
Pon1decreases hydrolysisISOPON1 (Homo sapiens)6480464CTDPON1 promoter SNP results in decreased hydrolysis of phenylacetic acidPMID:16117861
Pon1increases hydrolysisISOPON1 (Homo sapiens)6480464CTDPON1 protein results in increased hydrolysis of phenylacetic acidPMID:15375178 PMID:16052486 PMID:16117861 PMID:20176005 PMID:9746266
Pon1multiple interactionsISOPON1 (Homo sapiens)6480464CTD4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]PMID:15375178
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