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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620018
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gzmb
Name: granzyme B
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gzmbincreases expressionISOGZMB (Homo sapiens)6480464CTDPoly I-C results in increased expression of GZMB mRNA; Poly I-C results in increased expression of GZMB proteinPMID:23618096
Gzmbmultiple interactionsISOGZMB (Homo sapiens)6480464CTDParticulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB protein]PMID:23618096
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