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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619993
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp5f1a
Name: ATP synthase F1 subunit alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp5f1adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ATP5F1A proteinPMID:16548065
Atp5f1aaffects expressionISOAtp5f1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ATP5F1A mRNAPMID:21570461 PMID:24680724
Atp5f1aaffects localizationISOAtp5f1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the localization of ATP5F1A proteinPMID:21616089
Atp5f1adecreases expressionISOATP5F1A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ATP5F1A mRNAPMID:23152189
Atp5f1aincreases expressionISOAtp5f1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ATP5F1A mRNAPMID:17942748
Atp5f1amultiple interactionsISOATP5F1A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of ATP5F1A mRNA]PMID:11179685
Atp5f1amultiple interactionsISOAtp5f1a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5F1A mRNA; Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to ATP5F1A protein]PMID:17942748 PMID:21616089
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