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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991 Species: Rattus norvegicus RGD Object: Gene Symbol: Vegfa Name: vascular endothelial growth factor A

Acc ID: CHEBI:6541 Term: losartan Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position CasRN: 114798-26-4 Chemical ID: MESH:D019808

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731072	6480464	CTD	Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA] Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]	PMID:17481528
decreases expression	ISO	RGD:731072	6480464	CTD	Losartan results in decreased expression of VEGFA protein Losartan results in decreased expression of VEGFA mRNA	PMID:22188725
multiple interactions	EXP		6480464	CTD	Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]	PMID:12110003
multiple interactions	ISO	RGD:731072	6480464	CTD	Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA] Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein] Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]	PMID:17299153