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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991 Species: Rattus norvegicus RGD Object: Gene Symbol: Vegfa Name: vascular endothelial growth factor A

Acc ID: CHEBI:5855 Term: ibuprofen Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group. CasRN: 15687-27-1 Chemical ID: MESH:D007052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases secretion	ISO	RGD:731072	6480464	CTD	Ibuprofen results in decreased secretion of VEGFA protein	PMID:12912967
decreases expression	EXP		6480464	CTD	Ibuprofen results in decreased expression of VEGFA mRNA alternative form Ibuprofen results in decreased expression of VEGFA protein	PMID:16799050