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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaaffects expressionEXP 6480464CTDMifepristone affects the expression of VEGFA mRNAPMID:20686183
Vegfadecreases expressionEXP 6480464CTDMifepristone results in decreased expression of VEGFA mRNAPMID:25972201
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDMifepristone results in decreased expression of VEGFA proteinPMID:16638347
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDMifepristone inhibits the reaction [[Progestins results in increased activity of PGR protein] which results in increased expression of VEGFA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of VEGFA mRNA]; Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of VEGFA mRNA]; Mifepristone inhibits the reaction [Progestins results in increased expression of VEGFA mRNA]PMID:15845615 PMID:15860260 PMID:32619553
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