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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDArsenic results in increased expression of VEGFA proteinPMID:25559853
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA; [Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of VEGFA mRNA; CAT protein inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; cucurbitacin I inhibits the reaction [Arsenic results in increased expression of VEGFA protein]; diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; STAT3 protein affects the reaction [Arsenic results in increased expression of VEGFA protein]; VEGFA gene SNP affects the susceptibility to [Tobacco Smoke Pollution co-treated with Arsenic]PMID:21687637 PMID:23009795 PMID:25559853
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