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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDFluorouracil results in decreased expression of VEGFA mRNA; Fluorouracil results in decreased expression of VEGFA proteinPMID:17786339 PMID:17982676
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDFluorouracil results in decreased expression of VEGFA mRNA; Fluorouracil results in decreased expression of VEGFA proteinPMID:25936796 PMID:26272751 PMID:29678497 PMID:35235860
Vegfadecreases response to substanceISOVEGFA (Homo sapiens)6480464CTDVEGFA mRNA results in decreased susceptibility to Fluorouracil; VEGFA protein results in decreased susceptibility to FluorouracilPMID:18494554
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDFluorouracil results in increased expression of VEGFA mRNAPMID:17039268
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDFluorouracil results in increased expression of VEGFA proteinPMID:15817675
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDTP53 protein inhibits the reaction [Fluorouracil results in decreased expression of VEGFA mRNA]; VEGFA protein promotes the reaction [Fluorouracil results in decreased expression of IFNA1 protein]PMID:17786339 PMID:17982676
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDFluorouracil promotes the reaction [Resveratrol results in decreased expression of VEGFA protein]; Fluorouracil promotes the reaction [Valsartan results in decreased expression of VEGFA mRNA]; Resveratrol promotes the reaction [Fluorouracil results in decreased expression of VEGFA protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of VEGFA mRNA]PMID:25936796 PMID:35235860
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