GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | decreases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Fluorouracil results in decreased expression of VEGFA mRNA; Fluorouracil results in decreased expression of VEGFA protein | PMID:17786339 PMID:17982676 | Vegfa | decreases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Fluorouracil results in decreased expression of VEGFA mRNA; Fluorouracil results in decreased expression of VEGFA protein | PMID:25936796 PMID:26272751 PMID:29678497 PMID:35235860 | Vegfa | decreases response to substance | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | VEGFA mRNA results in decreased susceptibility to Fluorouracil; VEGFA protein results in decreased susceptibility to Fluorouracil | PMID:18494554 | Vegfa | increases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Fluorouracil results in increased expression of VEGFA mRNA | PMID:17039268 | Vegfa | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Fluorouracil results in increased expression of VEGFA protein | PMID:15817675 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of VEGFA mRNA]; VEGFA protein promotes the reaction [Fluorouracil results in decreased expression of IFNA1 protein] | PMID:17786339 PMID:17982676 | Vegfa | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Fluorouracil promotes the reaction [Resveratrol results in decreased expression of VEGFA protein]; Fluorouracil promotes the reaction [Valsartan results in decreased expression of VEGFA mRNA]; Resveratrol promotes the reaction [Fluorouracil results in decreased expression of VEGFA protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of VEGFA mRNA] | PMID:25936796 PMID:35235860 | |
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