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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDvorinostat results in decreased expression of VEGFA mRNA; vorinostat results in decreased expression of VEGFA proteinPMID:19509267 PMID:27188386
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDvorinostat results in decreased secretion of VEGFA proteinPMID:20421217
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Curcumin analog co-treated with vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; TNFSF10 protein promotes the reaction [vorinostat results in decreased expression of VEGFA protein]; vorinostat inhibits the reaction [TNF protein results in increased expression of VEGFA protein]PMID:16377638 PMID:19509267 PMID:20554536
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