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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of VEGFA proteinPMID:19967395
Vegfamultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]PMID:16598785
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDDexamethasone results in decreased expression of VEGFA mRNAPMID:25047013 PMID:32619553
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDDexamethasone results in decreased expression of VEGFA mRNA; Dexamethasone results in decreased expression of VEGFA proteinPMID:22733784 PMID:23210436 PMID:25912570
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDDexamethasone results in decreased secretion of VEGFA proteinPMID:15690317
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Dexamethasone results in increased expression of CAV1 protein] which results in decreased susceptibility to VEGFA protein; Dexamethasone inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of VEGFA mRNA]PMID:20801891 PMID:21420233 PMID:23426970 PMID:32619553
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA; Folic Acid inhibits the reaction [Dexamethasone results in decreased expression of VEGFA mRNA]PMID:25912570 PMID:33091441
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