GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | decreases expression | EXP | | 6480464 | CTD | Cyclosporine results in decreased expression of VEGFA mRNA; Cyclosporine results in decreased expression of VEGFA protein | PMID:24971338 | Vegfa | increases expression | EXP | | 6480464 | CTD | Cyclosporine results in increased expression of VEGFA mRNA; Cyclosporine results in increased expression of VEGFA protein | PMID:12110003 PMID:12639820 PMID:26276312 | Vegfa | multiple interactions | EXP | | 6480464 | CTD | Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA] | PMID:12110003 PMID:26276312 | Vegfa | decreases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Cyclosporine results in decreased expression of VEGFA mRNA; Cyclosporine results in decreased expression of VEGFA protein | PMID:26311998 | Vegfa | decreases methylation | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Cyclosporine results in decreased methylation of VEGFA promoter | PMID:27989131 | Vegfa | increases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Cyclosporine results in increased expression of VEGFA mRNA | PMID:20106945 PMID:33631201 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Cyclosporine inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein] | PMID:16682453 | Vegfa | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA mRNA]; Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA protein]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA mRNA]]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA protein]] | PMID:26311998 | |
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