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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDCyclosporine results in decreased expression of VEGFA mRNA; Cyclosporine results in decreased expression of VEGFA proteinPMID:24971338
Vegfaincreases expressionEXP 6480464CTDCyclosporine results in increased expression of VEGFA mRNA; Cyclosporine results in increased expression of VEGFA proteinPMID:12110003 PMID:12639820 PMID:26276312
Vegfamultiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]PMID:12110003 PMID:26276312
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDCyclosporine results in decreased expression of VEGFA mRNA; Cyclosporine results in decreased expression of VEGFA proteinPMID:26311998
Vegfadecreases methylationISOVEGFA (Homo sapiens)6480464CTDCyclosporine results in decreased methylation of VEGFA promoterPMID:27989131
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDCyclosporine results in increased expression of VEGFA mRNAPMID:20106945 PMID:33631201
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]PMID:16682453
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDAdenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA mRNA]; Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA protein]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA mRNA]]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA protein]]PMID:26311998
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