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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases activityEXP 6480464CTDCapsaicin results in decreased activity of VEGFAPMID:14744780
Vegfaincreases expressionEXP 6480464CTDCapsaicin results in increased expression of VEGFA proteinPMID:22150557
Vegfamultiple interactionsEXP 6480464CTD[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of VEGFA protein]PMID:22150557
Vegfadecreases activityISOVEGFA (Homo sapiens)6480464CTDCapsaicin results in decreased activity of VEGFAPMID:14744780
Vegfadecreases activityISOVegfa (Mus musculus)6480464CTDCapsaicin results in decreased activity of VEGFAPMID:14744780
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDCapsaicin results in decreased expression of VEGFA proteinPMID:17505005
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDCapsaicin results in increased expression of VEGFA mRNAPMID:12242509 PMID:21310942
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDCapsaicin results in increased secretion of VEGFA proteinPMID:12242509
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