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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDRotenone results in decreased expression of VEGFA mRNAPMID:33512557
Vegfaincreases secretionISOVegfa (Mus musculus)6480464CTDRotenone results in increased secretion of VEGFA proteinPMID:28903492
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rotenone inhibits the reaction [Acrolein results in increased expression of VEGFA protein]; Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Rotenone inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]PMID:17671207 PMID:19091749 PMID:19542490 PMID:22928487 PMID:23144690
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