GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | decreases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Cisplatin results in decreased expression of VEGFA mRNA; Cisplatin results in decreased expression of VEGFA protein | PMID:17498666 | Vegfa | increases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased expression of VEGFA mRNA | PMID:20935474 PMID:27594783 PMID:29690507 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | [[Cisplatin co-treated with ciglitazone] results in decreased expression of VEGFA] which results in decreased abundance of Dinoprostone; [Cisplatin co-treated with ciglitazone] results in decreased expression of VEGFA; [Cisplatin co-treated with Methotrexate co-treated with Doxorubicin] results in increased expression of VEGFA protein; [Cisplatin co-treated with Paclitaxel] results in increased expression of VEGFA mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of VEGFA mRNA; [Oxygen deficiency co-treated with eprenetapopt co-treated with Cisplatin] results in increased expression of VEGFA mRNA; Cisplatin promotes the reaction [HIF1A protein binds to VEGFA promoter]; eprenetapopt deficiency promotes the reaction [Cisplatin results in increased expression of VEGFA mRNA]; Topotecan inhibits the reaction [Cisplatin promotes the reaction [HIF1A protein binds to VEGFA promoter]]; Topotecan inhibits the reaction [Cisplatin results in increased expression of VEGFA mRNA] | PMID:20158913 PMID:20705681 PMID:20935474 PMID:21681689 PMID:29690507 PMID:30871063 | Vegfa | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of VEGFA mRNA]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of VEGFA mRNA]]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of VEGFA mRNA]] | PMID:37352108 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |