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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfamultiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of VEGFA mRNA]; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of VEGFA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of VEGFA mRNA; [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of VEGFA mRNA; [Lipopolysaccharides co-treated with TNF protein] results in increased expression of VEGFA mRNA; [Lipopolysaccharides co-treated with TNF protein] results in increased expression of VEGFA protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA proteinPMID:16415329 PMID:28844859 PMID:36049518
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of VEGFA mRNA; Lipopolysaccharides results in increased expression of VEGFA protein; Lipopolysaccharides results in increased expression of VEGFA protein polymorphismPMID:16385345 PMID:19744167 PMID:22087807 PMID:26918785 PMID:32186776 PMID:34978009
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of VEGFA mRNA; Lipopolysaccharides results in increased expression of VEGFA proteinPMID:12057914 PMID:26962056 PMID:34978009
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of VEGFA proteinPMID:24431307 PMID:32800949
Vegfaincreases secretionISOVegfa (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of VEGFA proteinPMID:34978009
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]]; HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]; idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]; Lipopolysaccharides inhibits the reaction [7-difluoromethyl-5,4'-dimethoxygenistein results in decreased expression of VEGFA mRNA]; Lipopolysaccharides inhibits the reaction [7-difluoromethyl-5,4'-dimethoxygenistein results in decreased expression of VEGFA protein]; Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein; Oxygen deficiency promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; TLR4 affects the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]PMID:19744167 PMID:20067761 PMID:22087807 PMID:26918785 PMID:32186776 PMID:34978009
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]; [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of VEGFA protein; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein]; Ethylene Chlorohydrin inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; idelalisib promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein; Vinyl Chloride metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]PMID:21327618 PMID:26918785 PMID:26962056 PMID:34978009
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