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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases expressionEXP 6480464CTDOxygen deficiency results in increased expression of VEGFA mRNA; Oxygen deficiency results in increased expression of VEGFA protein; Oxygen results in increased expression of VEGFA proteinPMID:10613739 PMID:10751333 PMID:10854229 PMID:11577072 PMID:11981751 PMID:12563064 PMID:18331222 PMID:18635243 PMID:19278353 PMID:22148982 PMID:22860425 PMID:23545307 PMID:33413359
Vegfaincreases secretionEXP 6480464CTDOxygen deficiency results in increased secretion of VEGFA proteinPMID:10613739 PMID:21296072
Vegfamultiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of VEGFA protein; AQP3 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; natakalim inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]; Resveratrol inhibits the reaction [Oxygen results in increased expression of VEGFA protein]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]PMID:10751333 PMID:11897773 PMID:18331222 PMID:18635243 PMID:19278353 PMID:21296072 PMID:22148982 PMID:22860425 PMID:23545307 PMID:33413359
Vegfaaffects expressionISOVegfa (Mus musculus)6480464CTDOxygen affects the expression of VEGFA mRNA; Oxygen affects the expression of VEGFA protein; Oxygen deficiency affects the expression of VEGFA mRNAPMID:17193925 PMID:22956610
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDOxygen results in decreased expression of VEGFA mRNA; Oxygen results in decreased expression of VEGFA proteinPMID:22363622 PMID:26272953
Vegfaincreases activityISOVEGFA (Homo sapiens)6480464CTDOxygen deficiency results in increased activity of VEGFA proteinPMID:18674879
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of VEGFA mRNA; Oxygen deficiency results in increased expression of VEGFA proteinPMID:10814519 PMID:10866824 PMID:11286986 PMID:11739637 PMID:11886167 PMID:12563064 PMID:13679210 PMID:15741220 PMID:16490744 PMID:17175027 PMID:17307335 PMID:17671207 PMID:17889387 PMID:17914565 PMID:17968679 PMID:17968710 PMID:18591213 PMID:18674879 PMID:19254699 PMID:19374849 PMID:19542490 PMID:19695866 PMID:20153296 PMID:20423107 PMID:20524035 PMID:20554536 PMID:20610613 PMID:21566342 PMID:22245592 PMID:22279137 PMID:22534113 PMID:22745725 PMID:23144690 PMID:23466666 PMID:23728938 PMID:25846647 PMID:26082309 PMID:26087400 PMID:26282490 PMID:26516004 PMID:26974319 PMID:27292261 PMID:28574600 PMID:29475939 PMID:29630948 PMID:29690507 PMID:29966676 PMID:30381462 PMID:8537383
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDOxygen deficiency results in increased expression of VEGFA mRNA; Oxygen deficiency results in increased expression of VEGFA protein; Oxygen results in increased expression of VEGFA proteinPMID:19074414 PMID:20412331 PMID:20880076 PMID:21048024 PMID:23437309 PMID:23539316 PMID:24639359 PMID:25203536 PMID:25511041 PMID:26723917 PMID:30682331
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDOxygen deficiency results in increased secretion of VEGFA proteinPMID:12147617 PMID:16490744 PMID:19542490 PMID:20153296 PMID:20423107 PMID:21994956 PMID:22652775 PMID:23466666 PMID:23728938 PMID:29630948 PMID:30851587
Vegfaincreases secretionISOVegfa (Mus musculus)6480464CTDOxygen results in increased secretion of VEGFA proteinPMID:29939353
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; [Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA protein; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Oxygen deficiency co-treated with eprenetapopt co-treated with Cisplatin] results in increased expression of VEGFA mRNA; [Oxygen deficiency co-treated with eprenetapopt] results in increased expression of VEGFA mRNA; [Polyphenols inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]] which results in decreased expression of VEGFA; [Propolis inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]] which results in decreased expression of VEGFA; [Quinolones co-treated with Oxygen deficiency] results in increased expression of VEGFA mRNA; [Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of VEGFA mRNA; annonacin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; annonacin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Apigenin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; bisphenol A promotes the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; butylbenzyl phthalate promotes the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; CGB3 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Cycloheximide promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Diethylhexyl Phthalate affects the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Estradiol promotes the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; fatostatin affects the reaction [Lipids deficiency inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]; fisetin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; fisetin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein]; galangin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein]; genipin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; genipin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Glucosamine inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; GSK1210151A promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; HIF1A protein alternative form inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; KC7F2 compound inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Lipids deficiency inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Luteolin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; molibresib inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; myricetin promotes the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Oxygen deficiency inhibits the reaction [ochratoxin A results in decreased expression of VEGFA protein]; Oxygen deficiency promotes the reaction [BRD4 protein binds to VEGFA promoter]; Oxygen deficiency promotes the reaction [HIF1A protein binds to VEGFA promoter]; Oxygen deficiency promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein; Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein; Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Polyphenols inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Polyphenols inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; POSTN protein affects the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; POSTN protein affects the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Propolis inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Propolis inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Quercetin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein]; Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Rotenone inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Silybin promotes the reaction [Lipids deficiency inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; ST6GAL1 protein affects the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; VEGFA protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:10866824 PMID:11286986 PMID:11739637 PMID:13679210 PMID:17671207 PMID:17764071 PMID:17889387 PMID:17968710 PMID:18072750 PMID:18575727 PMID:18591213 PMID:18674879 PMID:19091749 PMID:19254699 PMID:19542490 PMID:19695866 PMID:20153296 PMID:20423107 PMID:20524035 PMID:20554536 PMID:21554934 PMID:21566342 PMID:21994956 PMID:22087807 PMID:22279137 PMID:22745725 PMID:23144690 PMID:23466666 PMID:23555722 PMID:23728938 PMID:26082309 PMID:26087400 PMID:26282490 PMID:26974319 PMID:27292261 PMID:28574600 PMID:29475939 PMID:29630948 PMID:29690507 PMID:30851587 PMID:35513012 PMID:8537383
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of VEGFA protein; AKR1B1 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; ARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of VEGFA protein]; CYP1B1 gene mutant form promotes the reaction [Oxygen results in increased secretion of VEGFA protein]; HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; HMOX1 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; HMOX1 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; phosphomannopentaose sulfate affects the reaction [Oxygen affects the expression of VEGFA mRNA]; phosphomannopentaose sulfate affects the reaction [Oxygen affects the expression of VEGFA protein]; sorbinil inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]PMID:19074414 PMID:19228841 PMID:20412331 PMID:20880076 PMID:21048024 PMID:22956610 PMID:24639359 PMID:25203536 PMID:25511041 PMID:29939353 PMID:30682331
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