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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects methylationISOABCB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ABCB1 5' UTRPMID:27901495
Abcb1adecreases expressionISOAbcb1a (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ABCB1A mRNAPMID:19770486
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ABCB1 mRNAPMID:11096091
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ABCB1 mRNAPMID:15566942 PMID:16545412 PMID:17408918 PMID:21632981 PMID:26238291
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