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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619878
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgk1
Name: phosphoglycerate kinase 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgk1increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of PGK1 mRNA; cobaltous chloride results in increased expression of PGK1 proteinPMID:24386269
Pgk1increases expressionISOPGK1 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of PGK1 mRNAPMID:17553155 PMID:19502547 PMID:22202117 PMID:23958427 PMID:25100165
Pgk1multiple interactionsISOPGK1 (Homo sapiens)6480464CTDcobaltous chloride promotes the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of PGK1 mRNA]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PGK1 mRNA]PMID:22202117 PMID:23958427 PMID:25100165
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