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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl1decreases secretionEXP 6480464CTDSB 203580 results in decreased secretion of CXCL1 proteinPMID:28087833
Cxcl1multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of CXCL1 protein]; SB 203580 inhibits the reaction [resveratrol results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]PMID:21192278 PMID:23285267 PMID:28087833
Cxcl1multiple interactionsISOCXCL1 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [ADIPOQ protein results in increased expression of CXCL1 protein]; SB 203580 inhibits the reaction [nickel monoxide results in increased expression of CXCL1 protein]PMID:28176455 PMID:35006638
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