Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CXCL1 mRNA; Lipopolysaccharides results in increased expression of CXCL1 proteinPMID:15629513 PMID:18257742 PMID:24333275 PMID:32147387
Cxcl1increases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of CXCL1 proteinPMID:21504754
Cxcl1multiple interactionsEXP 6480464CTDAcetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]PMID:15237969 PMID:15629513 PMID:18257742 PMID:24333275 PMID:32147387
Cxcl1increases expressionISOCXCL1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CXCL1 mRNAPMID:19428942 PMID:22003094 PMID:35811015
Cxcl1increases secretionISOCXCL1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of CXCL1 proteinPMID:21913898 PMID:28065790
Cxcl1multiple interactionsISOCXCL1 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CXCL1 protein; [Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CXCL1 mRNA; [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CXCL1 mRNA; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CXCL1 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CXCL1 mRNA; Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]PMID:14997032 PMID:21572044 PMID:22003094 PMID:35811015 PMID:35877022 PMID:9122163
Go Back to source page   Continue to Ontology report