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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl1multiple interactionsISOCXCL1 (Homo sapiens)6480464CTDAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA]PMID:14742690 PMID:17303692
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