Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619831
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Fas
Name:	Fas cell surface death receptor

Acc ID:	CHEBI:42223
Term:	emodin
Definition:	A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID:	MESH:D004642

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Fas	decreases expression	EXP		6480464	CTD	Emodin results in decreased expression of FAS protein	PMID:19549930
Fas	increases expression	ISO	FAS (Homo sapiens)	6480464	CTD	Emodin results in increased expression of FAS protein	PMID:27032576
Fas	multiple interactions	ISO	FAS (Homo sapiens)	6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]	PMID:27032576

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