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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionEXP 6480464CTDCyclophosphamide results in increased expression of FAS mRNA; Cyclophosphamide results in increased expression of FAS proteinPMID:10393266 PMID:25446862
Fasmultiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of FAS mRNA]PMID:25446862
Fasdecreases expressionISOFAS (Homo sapiens)6480464CTDCyclophosphamide metabolite results in decreased expression of FAS mRNAPMID:24356939
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDCyclophosphamide results in increased expression of FASPMID:16166447
Fasincreases expressionISOFas (Mus musculus)6480464CTDCyclophosphamide results in increased expression of FASPMID:16166447
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTD[Cyclophosphamide co-treated with cacalol] results in decreased expression of FAS protein; [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FASPMID:16166447 PMID:20665104
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