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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831 Species: Rattus norvegicus RGD Object: Gene Symbol: Fas Name: Fas cell surface death receptor

Acc ID: CHEBI:16118 Term: berberine Definition: A berberine alkaloid that has formula C20H18NO4. CasRN: 2086-83-1 Chemical ID: MESH:D001599

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1552455	6480464	CTD	[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]	PMID:20564506
increases expression	ISO	RGD:1346266	6480464	CTD	Berberine results in increased expression of FAS mRNA Berberine results in increased expression of FAS protein	PMID:20656010