GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Acox1 | increases expression | EXP | | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA | PMID:18692542 PMID:18923995 PMID:19162173 PMID:19407336 PMID:19429409 PMID:21723365 | Acox1 | multiple interactions | EXP | | 6480464 | CTD | [perfluorooctane sulfonic acid results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein | PMID:15071170 | Acox1 | increases expression | ISO | Acox1 (Mus musculus) | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA; perfluorooctane sulfonic acid results in increased expression of ACOX1 protein | PMID:19429403 PMID:20936131 PMID:21705711 PMID:28558994 PMID:31926186 PMID:32979393 PMID:34861291 | Acox1 | multiple interactions | ISO | ACOX1 (Homo sapiens) | 6480464 | CTD | PPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA] | PMID:34861291 | Acox1 | multiple interactions | ISO | Acox1 (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of ACOX1 mRNA; [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of ACOX1 protein; [NR1H3 gene mutant form results in increased susceptibility to perfluorooctane sulfonic acid] which results in increased expression of ACOX1 mRNA; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ACOX1 mRNA; [perfluorooctane sulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of ACOX1 protein; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of ACOX1 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of ACOX1 mRNA; PPARA protein affects the reaction [perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA] | PMID:25949234 PMID:32979393 PMID:32991729 PMID:34861291 PMID:36331819 | | ||||||||||||||||||||||
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