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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61918
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc30a1
Name: solute carrier family 30 member 1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc30a1affects expressionEXP 6480464CTDZinc affects the expression of SLC30A1 mRNAPMID:15867272
Slc30a1affects localizationEXP 6480464CTDZinc affects the localization of SLC30A1 proteinPMID:21636019
Slc30a1affects transportEXP 6480464CTDSLC30A1 protein affects the transport of ZincPMID:21775119
Slc30a1decreases expressionEXP 6480464CTDZinc deficiency results in decreased expression of SLC30A1 proteinPMID:12421840
Slc30a1decreases response to substanceEXP 6480464CTDSLC30A1 mRNA results in decreased susceptibility to Zinc; SLC30A1 protein results in decreased susceptibility to Zinc; SLC30A1 results in decreased susceptibility to ZincPMID:15378655 PMID:7882967 PMID:9254680
Slc30a1increases expressionEXP 6480464CTDZinc results in increased expression of SLC30A1 mRNA; Zinc results in increased expression of SLC30A1 proteinPMID:15378655 PMID:21636019 PMID:9254680
Slc30a1multiple interactionsEXP 6480464CTDPentetic Acid affects the reaction [SLC30A1 protein affects the transport of Zinc]; SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; SLC30A1 protein promotes the reaction [[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]PMID:15041749 PMID:21775119
Slc30a1decreases expressionISOSlc30a1 (Mus musculus)6480464CTDZinc deficiency results in decreased expression of SLC30A1; Zinc deficiency results in decreased expression of SLC30A1 proteinPMID:18936201 PMID:19492079
Slc30a1decreases expressionISOSLC30A1 (Homo sapiens)6480464CTDZinc deficiency results in decreased expression of SLC30A1 mRNA; Zinc results in decreased expression of SLC30A1 mRNA; Zinc results in decreased expression of SLC30A1 proteinPMID:15753530 PMID:19720134 PMID:22171008
Slc30a1decreases uptakeISOSlc30a1 (Mus musculus)6480464CTDSLC30A1 protein results in decreased uptake of ZincPMID:19288494
Slc30a1increases expressionISOSlc30a1 (Mus musculus)6480464CTDZinc results in increased expression of SLC30A1; Zinc results in increased expression of SLC30A1 mRNAPMID:19288494 PMID:20133611
Slc30a1increases expressionISOSLC30A1 (Homo sapiens)6480464CTDZinc results in increased expression of SLC30A1 mRNA; Zinc results in increased expression of SLC30A1 proteinPMID:14568174 PMID:15226459 PMID:15276077 PMID:15867382 PMID:16434472 PMID:17473989 PMID:17622302 PMID:20479680
Slc30a1increases transportISOSLC30A1 (Homo sapiens)6480464CTDSLC30A1 protein results in increased transport of ZincPMID:18326752
Slc30a1increases uptakeISOSLC30A1 (Homo sapiens)6480464CTDSLC30A1 protein results in increased uptake of ZincPMID:18615482
Slc30a1multiple interactionsISOSlc30a1 (Mus musculus)6480464CTD[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; [MT1 protein co-treated with MT2 protein] promotes the reaction [SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; SLC30A1 inhibits the reaction [Zinc results in increased expression of and results in increased secretion of CLU protein]PMID:15041749 PMID:19288494
Slc30a1multiple interactionsISOSLC30A1 (Homo sapiens)6480464CTD[PCI 5002 co-treated with Zinc] results in increased expression of SLC30A1 mRNA; [Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; [Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SLC30A1 mRNA; Zinc inhibits the reaction [ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]]; Zinc results in increased expression of and affects the localization of SLC30A1 proteinPMID:15867382 PMID:18593933 PMID:19720134 PMID:19900532
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