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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61897
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptafr
Name: platelet-activating factor receptor
Acc ID: CHEBI:36707
Term: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Definition: A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine where the 2-O-acyl group is specified as acetyl; a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Chemical ID: MESH:D010972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptafrincreases expressionEXP 6480464CTDPlatelet Activating Factor results in increased expression of PTAFR mRNAPMID:10447766 PMID:9065783
Ptafrincreases phosphorylationEXP 6480464CTDPlatelet Activating Factor results in increased phosphorylation of PTAFR proteinPMID:11297424
Ptafrmultiple interactionsEXP 6480464CTDbepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]PMID:11297424 PMID:18205269 PMID:9065783
Ptafraffects bindingISOPTAFR (Homo sapiens)6480464CTDPlatelet Activating Factor binds to PTAFR proteinPMID:11529688 PMID:16386258
Ptafrincreases expressionISOPTAFR (Homo sapiens)6480464CTDPlatelet Activating Factor results in increased expression of PTAFR mRNAPMID:16386258
Ptafrmultiple interactionsISOPTAFR (Homo sapiens)6480464CTD1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]PMID:11529688 PMID:16386258
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