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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61888 Species: Rattus norvegicus RGD Object: Gene Symbol: Map2k2 Name: mitogen activated protein kinase kinase 2

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1343460	6480464	CTD	MAP2K2 protein results in decreased susceptibility to [Cisplatin co-treated with Fluorouracil] [U 0126 results in decreased activity of MAP2K2 protein] results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]	PMID:21444628
increases phosphorylation	ISO	RGD:1343460	6480464	CTD	Cisplatin results in increased phosphorylation of MAP2K2 protein	PMID:21444628
decreases response to substance	ISO	RGD:1343460	6480464	CTD	MAP2K2 results in decreased susceptibility to Cisplatin	PMID:21849418