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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9affects expressionEXP 6480464CTDDiazinon affects the expression of CASP9 mRNAPMID:17452286
Casp9increases cleavageEXP 6480464CTDDiazinon results in increased cleavage of CASP9 proteinPMID:27353299
Casp9multiple interactionsEXP 6480464CTDcrocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; Vitamin E inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]PMID:27353299
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDDiazinon results in increased activity of CASP9 proteinPMID:27920530
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDDiazinon results in increased expression of CASP9 mRNAPMID:27920530
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDMagnesium Oxide analog inhibits the reaction [Diazinon results in increased activity of CASP9 protein]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP9 mRNA]; Selenium analog inhibits the reaction [Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP9 mRNA]]PMID:27920530
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