GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp9 | increases activity | EXP | | 6480464 | CTD | Camptothecin results in increased activity of CASP9 protein | PMID:16263807 | Casp9 | multiple interactions | EXP | | 6480464 | CTD | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP9 protein]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP9 protein] | PMID:16263807 PMID:19497415 | Casp9 | decreases expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Camptothecin results in decreased expression of CASP9 mRNA | PMID:30581319 | Casp9 | increases activity | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Camptothecin results in increased activity of CASP9 protein | PMID:34635930 | Casp9 | increases cleavage | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Camptothecin results in increased cleavage of CASP9 protein | PMID:10896673 PMID:24823293 | Casp9 | increases expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Camptothecin results in increased expression of CASP9 protein | PMID:30885713 | Casp9 | multiple interactions | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein] | PMID:15958570 PMID:19633536 PMID:30885713 | |
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