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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp9 Name: caspase 9, apoptosis-related cysteine peptidase

Acc ID: CHEBI:15738 Term: staurosporine Definition: An indolocarbazole alkaloid that has formula C28H26N4O3. CasRN: 62996-74-1 Chemical ID: MESH:D019311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69147	6480464	CTD	Staurosporine results in increased cleavage of and results in increased activity of CASP9 protein	PMID:16007152
multiple interactions	EXP		6480464	CTD	3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein] Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]	PMID:16497721
multiple interactions	ISO	RGD:69147	6480464	CTD	ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]	PMID:20338155
increases activity	ISO	RGD:69147	6480464	CTD	Staurosporine results in increased activity of CASP9 protein	PMID:20338155
increases activity	ISO	RGD:69147	6480464	CTD	Staurosporine results in increased activity of CASP9 protein	PMID:19352495 PMID:20338155