Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9decreases expressionISOCasp9 (Mus musculus)6480464CTDTretinoin results in decreased expression of CASP9 mRNAPMID:22498432
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDTretinoin results in increased activity of CASP9 proteinPMID:16291826
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDTretinoin results in increased activity of CASP9 proteinPMID:16568081
Casp9increases expressionISOCasp9 (Mus musculus)6480464CTDTretinoin results in increased expression of CASP9 proteinPMID:16764683
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDTretinoin results in increased expression of CASP9 mRNAPMID:15498508 PMID:16166294 PMID:23830798 PMID:33167477
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Tretinoin results in increased activity of CASP9 protein]PMID:16291826
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[IFNB1 protein co-treated with Tretinoin] results in increased cleavage of and results in increased activity of CASP9 protein; [Tretinoin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP9 protein; CRABP2 protein promotes the reaction [Tretinoin results in increased cleavage of and results in increased activity of CASP9 protein]; CRABP2 protein promotes the reaction [Tretinoin results in increased expression of CASP9 mRNA]; Tretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]; Tretinoin results in increased cleavage of and results in increased activity of CASP9 proteinPMID:16166294 PMID:16826196 PMID:17387344 PMID:17701358 PMID:23747833
Go Back to source page   Continue to Ontology report