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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aincreases expressionEXP 6480464CTDCorticosterone results in increased expression of HTR2A mRNAPMID:15755911 PMID:18363858
Htr2aincreases secretionEXP 6480464CTDHTR2A protein results in increased secretion of CorticosteronePMID:19304867
Htr2amultiple interactionsEXP 6480464CTD[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone]; [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]PMID:19304867 PMID:19879056
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