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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:65585
Term: carnosic acid
Definition: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Chemical ID: MESH:C018381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDsalvin results in increased expression of VDR proteinPMID:11504768
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTDCalcitriol promotes the reaction [salvin results in increased expression of VDR protein]; Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein]; Tretinoin promotes the reaction [salvin results in increased expression of VDR protein]PMID:11504768
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