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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdraffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of VDR mRNAPMID:34747641
Vdraffects expressionISOVdr (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of VDR mRNAPMID:21570461
Vdrdecreases expressionISOVdr (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of VDR mRNAPMID:24035824
Vdrincreases expressionISOVdr (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of VDR mRNAPMID:15667827 PMID:24058054 PMID:29673856
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of VDR mRNAPMID:20106945 PMID:22903824 PMID:28011154
Vdrmultiple interactionsISOVdr (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to VDR promoter]PMID:19654925
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of VDR mRNAPMID:26159488
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