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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1affects expressionEXP 6480464CTDbisphenol A affects the expression of UGT1A1 mRNAPMID:30903817
Ugt1a1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of UGT1A1 mRNAPMID:26496021
Ugt1a1affects glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 polymorphism affects the glucuronidation of bisphenol APMID:22154984
Ugt1a1decreases expressionISOUgt1a1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of UGT1A1 mRNAPMID:33221593
Ugt1a1decreases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein polymorphism results in decreased glucuronidation of bisphenol APMID:26999266
Ugt1a1increases expressionISOUgt1a1 (Mus musculus)6480464CTDbisphenol A results in increased expression of UGT1A1 mRNAPMID:21932408
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of UGT1A1; bisphenol A results in increased expression of UGT1A1 mRNAPMID:22214767 PMID:31207516 PMID:36893891
Ugt1a1increases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein results in increased glucuronidation of bisphenol APMID:18990428
Ugt1a1multiple interactionsISOUgt1a1 (Mus musculus)6480464CTD[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA; [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA]PMID:23756648 PMID:28123100
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