GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ugt1a1 | increases activity | ISO | UGT1A1 (Homo sapiens) | 6480464 | CTD | Hymecromone results in increased activity of UGT1A1 protein | PMID:26875642 | Ugt1a1 | increases glucuronidation | ISO | UGT1A1 (Homo sapiens) | 6480464 | CTD | UGT1A1 protein results in increased glucuronidation of Hymecromone | PMID:15378558 PMID:15593333 PMID:15802387 PMID:33290829 PMID:34044055 | Ugt1a1 | increases metabolic processing | ISO | UGT1A1 (Homo sapiens) | 6480464 | CTD | UGT1A1 protein results in increased metabolism of Hymecromone | PMID:31812603 | Ugt1a1 | multiple interactions | ISO | UGT1A1 (Homo sapiens) | 6480464 | CTD | [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; osimertinib inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] | PMID:15378558 PMID:26875642 PMID:31812603 PMID:33290829 PMID:34044055 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |